Imbruvica 140mg (Ibrutinib) is a revolutionary targeted therapy widely prescribed for several blood cancers. This blog post provides an A to Z overview of Imbruvica 140mg, including how it works, its uses, benefits, safety advice, patient assistance programs, and answers to frequently asked questions. Whether you’re a patient, caregiver, or healthcare professional, this guide will help you understand this important medicine better.

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What is Imbruvica 140mg?

Imbruvica 140mg is an oral medication containing the active ingredient Ibrutinib, a Bruton’s tyrosine kinase (BTK) inhibitor. BTK plays a key role in the growth and survival of certain cancer cells. By blocking BTK, Imbruvica slows tumor progression and promotes cancer cell death. It is primarily used in blood cancers like:

• Chronic Lymphocytic Leukemia (CLL)
• Mantle Cell Lymphoma (MCL)
• Small Lymphocytic Lymphoma (SLL)
• Waldenstrom’s Macroglobulinemia (WM)
• Marginal Zone Lymphoma (MZL)
• Chronic Graft Versus Host Disease (cGvHD)

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How Does Imbruvica 140mg Work?

Imbruvica targets the BTK enzyme, interrupting the signaling pathways that cancer cells rely on for survival and proliferation. This targeted mechanism makes it a less invasive alternative to traditional chemotherapy, offering sustained disease control and improved survival rates in many patients.

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Patient Assistance Programs for Imbruvica 140mg

Johnson & Johnson offers Patient Assistance Programs to help eligible Indian patients access Imbruvica 140mg at a more affordable cost. The program typically covers chronic lymphoid leukemia (CLL) and NCL conditions. Patients purchasing one bottle may receive an additional bottle free under the program.

Eligibility criteria include:

• A valid prescription from a certified oncologist
• Indian citizenship with proper identity proof
• Meeting specific medical and program requirements

For assistance, patients can contact support teams at authorized centers or via email: info@zyloxd.com. Zyloxd also provides free consultations to help patients navigate these programs but is not directly affiliated with them.

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Uses and Indications of Imbruvica 140mg

Imbruvica 140mg is used to treat:

• Mantle Cell Lymphoma (MCL)
• Chronic Lymphocytic Leukemia (CLL)
• Small Lymphocytic Lymphoma (SLL)
• Waldenstrom’s Macroglobulinemia (WM)
• Chronic Graft Versus Host Disease (cGvHD) after failure of systemic therapy

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How to Take Imbruvica

• Take the capsule orally at the same time every day.
• Swallow whole; do not chew or crush.
• Avoid consuming grapefruit, Seville oranges, or related products during treatment.
• Maintain adequate hydration to avoid dehydration.

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Safety and Precautions

Before starting Imbruvica 140mg, inform your physician if you have:

• Bleeding disorders
• Liver or kidney problems
• Heart conditions
• History of infections or immune issues
• Plans for surgery (may require stopping medication temporarily)

Important Safety Tips:

• Use effective contraception during treatment and for one month after the last dose.
• Avoid alcohol, as it may increase liver risks.
• Do not breastfeed during treatment and for at least a week after stopping.
• Be cautious when driving or operating machinery if you experience dizziness or fatigue.

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Side Effects of Imbruvica 140mg

Common Side Effects:

• Nausea and vomiting
• Diarrhea
• Fatigue and weakness
• Muscle and bone pain
• Rash and bruising

Serious Side Effects:

• Bleeding complications
• Severe infections
• Heart problems, including arrhythmia
• Secondary cancers
• Tumor lysis syndrome

Seek immediate medical attention if you experience unusual bleeding, chest pain, severe infections, or allergic reactions.

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Drug Interactions

Imbruvica 140mg is metabolized by the CYP3A enzyme system. Avoid combining it with:

• Strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin) which may increase toxicity.
• Strong CYP3A inducers (e.g., rifampin, carbamazepine) which may reduce effectiveness.
• Grapefruit and Seville oranges due to interaction risks.

Always inform your healthcare provider about all medicines and supplements you take.

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Frequently Asked Questions (FAQs)

Q1: Can Imbruvica 140mg prevent cancer?
No, it treats specific blood cancers but is not a preventive medicine.

Q2: Can I take Imbruvica with other medications?
Yes, but inform your doctor due to possible drug interactions.

Q3: How long will I need to take Imbruvica?
Treatment duration varies by condition and response; your doctor will guide you.

Q4: Is alcohol safe during treatment?
Alcohol consumption is not recommended.

Q5: Does Imbruvica cure all blood cancers?
No, it is effective only for certain types of blood cancers.

Q6: Should I use contraception during treatment?
Yes, use contraception during and for one month after treatment.

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Storage and Handling

• Store Imbruvica 140mg capsules in original packaging at 20–25°C.
• Keep out of reach of children.

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Final Thoughts

Imbruvica 140mg is a breakthrough medicine offering hope to patients with certain blood cancers. With the support of Patient Assistance Programs, eligible patients can access this vital treatment affordably. Always consult your healthcare provider for personalized advice and never alter your prescribed dose without medical guidance.

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References

• EMC – Medicines Information
• FDA Prescribing Information
• PubMed Article on Ibrutinib
• FDA Drug Approval

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