Depo-Provera (medroxyprogesterone acetate) prevents pregnancy for 12 to 14 weeks with a single injection. It works by stopping ovulation and thickening cervical mucus, making pregnancy unlikely. Additionally, it provides a convenient long-term solution for individuals who do not want daily pills. Learn more about how it works on Mayo Clinic.
Key Benefits & Uses
Depo-Provera offers highly effective contraception, with over 99% success when used correctly. Moreover, its non-estrogenic formulation suits people who cannot or prefer not to take estrogen. Only four injections are needed per year, making it very convenient. In addition, it may reduce menstrual cramps, decrease bleeding, and lower the risk of endometrial cancer. Detailed information is available on Drugs.com and WebMD.
How to Use
A healthcare professional administers Depo-Provera via intramuscular injection every 12 to 14 weeks. For home use, a subcutaneous version called Depo-SubQ Provera 104 is available under medical supervision. Therefore, users can choose the method that works best. For more guidance, visit FDA or Healthline.
Important Safety Information
Long-term use may reduce bone strength. Depo-Provera should not be used during pregnancy and is safe during breastfeeding only with medical advice. Some medications, like St. John’s wort, may reduce its effectiveness. Additionally, patients should inform their doctor about any history of breast cancer, liver disease, or blood clots. For full safety details, see PubMed and WHO.
Common Side Effects
Common side effects include:
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Irregular or absent periods
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Headaches
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Weight gain
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Mood changes
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Stomach discomfort
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Decreased libido
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Bone density loss with prolonged use
More details are available on WebMD and Drugs.com.
Why Choose Depo-Provera?
Depo-Provera provides a simple, long-lasting method to prevent pregnancy. Moreover, its non-estrogen formulation suits many individuals. In addition, it can reduce menstrual discomfort, making it convenient and effective. Learn why Depo-Provera may be right for you on Mayo Clinic and Healthline.

