Prothiaden contains the active ingredient dosulepin, a tricyclic antidepressant (TCA) that doctors primarily prescribe to treat major depressive disorder. It blocks the reuptake of serotonin and norepinephrine, which enhances mood and reduces depressive symptoms. Additionally, healthcare providers may prescribe dosulepin off-label to manage chronic pain and prevent migraines. You can find more information at Mayo Clinic, Drugs.com, FDA, WebMD, PubMed, Healthline, WHO, and MedlinePlus.
Key Benefits & Uses
Prothiaden effectively treats major depressive disorder, alleviates anxiety related to depression, manages certain types of chronic pain, and reduces migraine frequency. Moreover, its dual-action on serotonin and norepinephrine ensures comprehensive therapeutic benefits. You can read additional research at Mayo Clinic and PubMed.
How to Use
Doctors typically prescribe 75mg to 150mg daily for depression, with a maximum of 225mg. For chronic pain or migraine prevention, they usually recommend 75mg daily. Take Prothiaden once daily, preferably before bedtime, to minimize daytime drowsiness. Also, take it at the same time each day for optimal results. If you miss a dose, take it as soon as you remember unless the next dose is near. Avoid doubling doses. For detailed instructions, visit Drugs.com and MedlinePlus.
Important Safety Information
Avoid Prothiaden if you have hypersensitivity to dosulepin, recently experienced a heart attack, or have severe liver problems. Additionally, do not combine it with monoamine oxidase inhibitors (MAOIs) or use it within 14 days of stopping them due to the risk of serotonin syndrome. Limit alcohol consumption because it may increase sedative effects. Furthermore, consult a healthcare provider before using it during pregnancy or breastfeeding. Visit FDA and WHO for safety guidance.
Common Side Effects
Patients often experience drowsiness, dry mouth, blurred vision, constipation, urinary retention, dizziness, and increased sweating. Less frequently, they may develop tremors, skin rashes, changes in sexual function, or low blood pressure. Serious side effects include heart rhythm disturbances, liver issues, seizures, and suicidal thoughts. Seek immediate medical attention if these occur. For more details, check WebMD and Healthline.
Why Choose Prothiaden
Prothiaden offers an affordable option to manage depression and related symptoms. Its dual-action mechanism improves mood and reduces anxiety. However, due to its toxicity in overdose, doctors usually prescribe it only when other antidepressants fail. Learn more at Mayo Clinic and PubMed.

