Tri-Luma Cream is a dermatologist-recommended topical treatment combining Fluocinolone (a mild corticosteroid), Hydroquinone (a skin-lightening agent), and Tretinoin (a retinoid). This unique triple-combination formula is widely prescribed for the short-term treatment of moderate-to-severe melasma of the face. Clinical studies published on PubMed confirm its effectiveness in reducing dark spots and improving overall skin tone when used as directed under medical supervision.
Key Benefits & Uses
-
Reduces melasma and hyperpigmentation caused by sun exposure, hormonal changes, or aging.
-
Promotes brighter and clearer skin tone.
-
Supports skin renewal by increasing cell turnover.
-
Combines anti-inflammatory, bleaching, and exfoliating effects for fast, visible results.
-
Widely studied and approved by the FDA for safety and efficacy in melasma treatment.
For more detailed insights on melasma and pigmentation disorders, you can visit Mayo Clinic, Drugs.com, and WebMD.
How to Use
-
Apply a thin layer of Tri-Luma Cream to the affected area once daily in the evening.
-
Use only on the face, avoiding eyes, nose, and mouth.
-
Always apply broad-spectrum sunscreen during the day, as Hydroquinone and Tretinoin increase sun sensitivity.
-
Follow your dermatologist’s guidance for treatment duration (usually up to 8 weeks).
Refer to Healthline for skincare tips when using retinoid-based treatments.
Important Safety Information
-
For external use only.
-
Avoid prolonged sun exposure, tanning beds, and harsh skin products.
-
Not recommended during pregnancy or breastfeeding unless advised by a doctor.
-
Consult your dermatologist before combining with other topical medications.
-
Learn more about skin safety from the World Health Organization (WHO).
Common Side Effects
-
Mild redness, dryness, or itching.
-
Temporary burning or peeling of the skin.
-
Increased sensitivity to sunlight.
-
If severe irritation or allergic reaction occurs, discontinue use and seek medical advice.
Additional details on side effects can be found on Drugs.com.
Why Choose Tri-Luma Cream?
Tri-Luma is the only FDA-approved triple-combination therapy for facial melasma, offering superior results compared to single-ingredient creams. It is trusted worldwide by dermatologists and supported by clinical studies (PubMed) for its safety and effectiveness in reducing pigmentation and restoring skin clarity.

